TNF and liver cancer: Another proinflammatory cytokine, TNF-α which is considered as an NF-κB activator, produced during the inflammatory response, assumes a noteworthy part in inflammation and is termed as a cell multiplication accelerator.43 Our results demonstrated the lower content of TNF-α in DEN-induced hepatic cancer Wistar rats, which was downregulated by MLAgNPs, affirming the improved level of TNF-α close to the level in the control group rats.