KL and congenital bilateral aplasia of vas deferens from CFTR mutation: These features are missing in many preclinical models of CAVD that are, for instance, based on hyperlipidemic animals, where valvular calcification is either absent or predominantly involves the annulus with some involvement of the leaflets, or Klotho deficiency, where the leaflets are not thickened and the animals do not develop aortic stenosis.24