We evaluated DCBLD2 expression by immunostaining in normal human aortic valves obtained from deceased organ donors, and aortic valves with advanced CAVD obtained from patients undergoing aortic valve replacement for symptomatic aortic stenosis (Figure 1A, Supplemental Figure 1A). The gene discussed is DCBLD2; the disease is congenital bilateral aplasia of vas deferens from CFTR mutation.