Piperlongumine was docked with the HCC targets such as vascular endothelial growth factor (VEGF), epidermalgrowth factor receptor, Aurora-2, Nuclear factor Kappa-B (NF-KB), Jak2 Kinase, Fibroblast growth factor receptor 4, Bcl-2-like protein 1,Apopain, and Apoptosis regulator Bcl-2 using in-silico technique with the software grid-based ligand dockingwith energies. The gene discussed is FGFR4; the disease is hepatocellular carcinoma.