TP53 and neoplasm: Protein encoded by p53 gene is a transcription factor that is responsible for DNA repair, cell cycle arrest and apoptosis.1–3 Mutations of the p53 gene are observed in more than 50% of human tumor tissues, and they are considered to be the major pathogenic factor for human tumors.4–6 Once a p53 gene mutates it loses the regulation of various physiological activities of cells as a result of its spatial conformation, and ultimately the p53 gene is transformed from a tumor suppressor gene into an oncogene.