(Z)-N-(3-Chlorophenyl)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetamide (SKLB023, Fig. 1), is a novel small-molecule iNOS inhibitor based on thiazolidine-2,4-dione moiety.19 In our previous studies, SKLB023 was found to block joint inflammation and cartilage destruction of arthritis.19 However, the antifibrotic effects of SKLB023 in chronic kidney disease remain unclear. This evidence concerns the gene NOS2 and Arthritis.