NOS2 and arthritic joint disease: (Z)-N-(3-Chlorophenyl)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetamide (SKLB023, Fig. 1), is a novel small-molecule iNOS inhibitor based on thiazolidine-2,4-dione moiety.19 In our previous studies, SKLB023 was found to block joint inflammation and cartilage destruction of arthritis.19 However, the antifibrotic effects of SKLB023 in chronic kidney disease remain unclear.