If the HBMSCs fail to completely repair local bone defects caused by infection, it can cause local osteoporosis and pathologic fracture.34 Currently, drugs that function as bone absorption inhibitors by suppressing osteoclast activity such as vitamin D analogues, calcitonin,35 and estrogen,36 are used in osteoporosis treatment.37 However, these drugs do not promote osteogenic differentiation, nor do they possess antibacterial properties. This evidence concerns the gene CALCA and osteoporosis.