An earlier study reported that tropisetron reduces the inward cation currents, particularly calcium cation, which is the main target for sulfonylureas, which are the classical insulin secreting agents.28 Having secretagogue action and anti-inflammatory characters, tropisetron was the drug investigated in the current study to unveil possible mechanisms in T2DM both centrally and peripherally using a T2DM rat model. Here, INS is linked to type 2 diabetes mellitus.