A previous study13 showed that both insulin and 5-HT decreased in a T2DM mouse model, while El-Marasy et al. (2014) reported that the antidepressant drug hesperidin used by diabetic depressive patients abated hyperglycemia and inflammation and elevated 5-HT level.14 On the contrary, other researchers reported that pregnant women who used selective 5-HT reuptake inhibitors (SSRI) gave birth to off springs with abnormal glycemic control15 and that 5-HT increases with inflammatory diseases including T2DM.16 The gene discussed is INS; the disease is Hyperglycemia.