ALOX5 and neoplasm: Furthermore, the metabolites of arachidonic acid, including 5-HETE, 12-HETE, and TLB4, could promote the phosphorylation of MEK/ERK and inhibit the apoptosis of tumor cells.26,27 5-OXE-ETE is a product of 5-HETE via the 5-lipoxygenase pathway, and could inhibit apoptosis of tumor cells via the 5-LO inhibitors.28 In this study, the levels of TLB4 and 5-OXE-ETE had a significant increase compared with those of the control group.