FASN and cancer: Fatty acid synthase (FASN) is an essential lipogenic enzyme catalyzing the ultimate process in the de novo biosynthesis of palmitate from acetyl–CoA and malonyl–CoA, and is frequently found in elevated levels in numerous cancers, including hepatocarcinoma.20 AKT/mTORC1 is supposed to be a trigger of FASN-mediated lipogenesis during carcinogenesis.