HGF and hepatocellular carcinoma: The active HGF/c-Met signaling pathway in an aggressive growth enhances cell survival, invasion and metastasis,5 and is positively correlated with a bad prognosis of HCC.6 In this respect, c-Met might be synergistic with accelerating PI3K/AKT-induced hepatic malignancy and could be an available therapeutic target for HCC remedies.