Therefore, equine lysozyme is allowed to re-fold to a native conformation.76 In an experimental study using PC12 cells (single rat adrenal pheochromocytoma) to demonstrate accumulation of equine lysozyme–OA complex at the plasma membrane, the membrane was perturbed and the complex quickly internalized and filled the cell after 1 h, as determined by live microscopy.77 All of the examined protein–lipid complexes have been found to have a significant effect on lipid membranes, consequently enhancing membrane modifications as a possible description for the initiation of cell death.71 The gene discussed is LYZ; the disease is adrenal gland pheochromocytoma.