HK1 and neoplasm: Definitely, glycolysis inhibition is already a potent scenario effectively used for tumor therapy118 and OA is a potent inhibitor of numerous glycolytic enzymes.124 Free OA was found to inhibit hexokinase I,125 whose function is converting glucose into glucose-6-phosphate in the glycolysis cycle.126,127 Hence, utilizing protein–lipid complexes like HAMLET as a carriers of fatty acids like OA might be beneficial to modify tumor cell metabolism and perturb the glycolysis cycle, which is stimulated in tumor cells owing to the Warburg effect as mentioned above.