One function of albumin is carrying and solubilizing the long chain fatty acids which allow the binding of free fatty acids, as in HAMLET and HAMLET-like complexes, neutralizing the cytotoxic activity of these complexes.4,18,57 Also, due to the existence of albumin in most physiological fluids, HAMLET and HAMLET-like complexes will have difficulty reaching the target tumor cells in a cytotoxic form. This evidence concerns the gene ALB and neoplasm.