NFE2L2 and cancer: Then tumor cell metabolism will be damaged and the proliferation will be abnormal.16,17 Thus, inhibiting Nrf2 is a normal strategy for the effective treatment of cancer.18 Therefore, whether the activated state of the Nrf2 signaling pathway is normal or not determines its double roles in cancer.19 Previously, some studies have indicated that Nrf2 inhibitors can interrupt the signaling pathway of Nrf2–ARE.