Output data from this study showed BJEE inhibited the cell proliferation of HCT-116 colon cancer cells at IC50 value of 8.9 ± 1.32 (μg mL−1) and significantly increased the levels of caspase-8, 9, and 3/7 in treated cells in comparison to untreated. Here, CASP8 is linked to malignant colon neoplasm.