Interestingly, the lack of CD54 (ICAM‐1) and CD29 (integrin beta‐1) adherence molecules expression by tumor cells in our cohort compared with tumor cells of DLBCL NOS, suggests a loss of expression of those “homing” molecules and reinforces the hypothesis that this peculiar and exclusive intravascular growth pattern is secondary to this defect of homing receptors expression by neoplastic cells (Ponzoni, 2000).2 Here, ITGB1 is linked to diffuse large B-cell lymphoma.