TNF and Alzheimer disease: As expected, specific DEGs in KELS were associated with a predicted increase in several upstream pro‐inflammatory mediators including Th2‐, Th1‐ and Th17‐associated factors (e.g. TNF, IFNG, IL1B and IL6; Figure 1B and C; Table S4) highlighting the interplay between keratinocytes and immune cells in moderate‐to‐severe AD (Figure 1C).