We identified that T cells are the primary source of IFNG (IFNγ), TNF (TNFα), IL4 (IL‐4) and IL13 (IL‐13), macrophages/dendritic cells are the main producer of IL1B (IL‐1β) and keratinocytes are significant producers of TSLP, IL6 and IL33 in AD lesional skin. Here, IFNG is linked to Alzheimer disease.