IL6 and Alzheimer disease: However, part of the activation of Th1 (z‐score 1.34) and Th2 (z‐score 1) pathways and IL15 (z‐score 2), IL‐22 (z‐score 1), IL‐3 (z‐score 1.65), IL‐6 (z‐score 2.34), IL‐7 (z‐score 1.65), IL‐8 (z‐score 3.46) and CXCR4 (z‐score 2.50) signalling appear to be driven by EGFR signalling in AD lesional keratinocytes (Figure 2C).