We identified that T cells are the primary source of IFNG (IFNγ), TNF (TNFα), IL4 (IL‐4) and IL13 (IL‐13), macrophages/dendritic cells are the main producer of IL1B (IL‐1β) and keratinocytes are significant producers of TSLP, IL6 and IL33 in AD lesional skin. This evidence concerns the gene IL1B and Alzheimer disease.