This study identifies key gliogenic genes/signaling pathways having the ability to control oncogenesis in glioblastoma cells including p300, BMP, PAX6 (anti-GBM override), HOPX (tumor suppressive + differentiation), NRSF/REST (astrcytogenic but capable of playing oncogenic role), LIF, and TGF beta. This evidence concerns the gene EP300 and glioblastoma.