HES3 and glioblastoma: Key genes that contribute to neurogenesis but also contribute to the stemness in GBM: klf4, myc, oct2, sox4, TLF TF, wnt signaling, sox2, sox4, Notch/STAT3-Ser/Hes3 Axis, and GSK3beta also work with PI3K/FGF signaling pathway and contribute to stability of c-myc.Wnt signaling: It is kept in check by tumor suppressors and is more involved in neurogenesis.