BRAF and neoplasm: For example, Kopetz et al. established an Avatar model of colorectal cancer with BRAF mutation, which by using vemurafenib as an oral BRAF inhibitor, drug resistance was observed due to KRAS (Kirsten Rat Sarcoma Virus) and NRAS (Neuroblastoma RAS Viral Oncogene Homolog) mutations at low allele frequency in this tumor subset [49].