Although the function of BCRP3 in cancer remains elusive, our finding for the upregulation of BCRP3 in response to certain proteotoxic stresses and its effect on aggrephagy induction for maintaining proteostasis and cell viability imply an impact of BCRP3 on preventing pathological states associated with the accumulation of proteinaceous inclusions. This evidence concerns the gene BCRP3 and cancer.