WES revealed AD variants of NLRP12 [C.1054>T, minor allele frequency (MAF) 0.04%] and IRF2BP2 (c.1180A>C, MAF 0.006%), and heterozygous, autosomal recessive, pathological variant of ATM (c.7089+2T>G). Here, IRF2BP2 is linked to Alzheimer disease.