APC was highly methylated in 7/22 (31.8%) of primary NSCLC tissues when compared to SLFN11, SHOX2 and FOXA1 (4/22: 18.2% each of them), whereas DNA methylation of RASSF1a was detected in only two samples (Fig. 2b). This evidence concerns the gene SLFN11 and non-small cell lung carcinoma.