The TIGIT-NECTIN2 relationship, for example, was shared across CAFS1 subtypes and CD8+ T cells, but the T cell ligand- receptor inhibitory signal (LGASL9-HAVCR2) was specific to the ecm-myCAF and CD8+ GZMB pair which was abundant in our MSI-H CRC dataset. This evidence concerns the gene TIGIT and colorectal carcinoma.