The top 10 pathways are visually displayed in Fig. 5B. Amyotrophic lateral sclerosis, Epstein-Barr virus infection, hepatitis C, Huntington’s disease, influenza A, oxidative phosphorylation, Parkinson’s disease, prion disease, proteasome, and systemic lupus erythematosus were differentially enriched in ISG15 high expression samples. Here, ISG15 is linked to Huntington disease.