ISG15 and prion disease: The top 10 pathways are visually displayed in Fig. 5B. Amyotrophic lateral sclerosis, Epstein-Barr virus infection, hepatitis C, Huntington’s disease, influenza A, oxidative phosphorylation, Parkinson’s disease, prion disease, proteasome, and systemic lupus erythematosus were differentially enriched in ISG15 high expression samples.