As one of the three rate-limiting enzymes of glycolysis, pyruvate kinase includes four isozymes, of which M2-type pyruvate kinase (PKM2) is mainly expressed in rapidly proliferating cells, especially tumor cells, and it plays a crucial role in the development of tumors, such as GBM, [9] by regulating aerobic glycolysis. Here, PKM is linked to glioblastoma.