PKM2 dimerization causes its enzymatic activity to decrease; hence, we detected PKM2 enzymatic activity in JMJD5-transfected GBM cells, and the results demonstrate that JMJD5 can equally promote PKM2 dimerization in GBM cells and thereby promote glycolysis and proliferation in GBM cells. Here, KDM8 is linked to glioblastoma.