KDM8 and neoplasm: Subsequently, we transfected JMJD5-WT, JMJD5-S361A, and JMJD5-S361E plasmids into U251 and U373 cells and found that JMJD5 with low phosphorylation levels significantly increased glucose consumption, lactate production, proliferation, and ECAR in U251 and U373 cells and promoted xenograft tumor growth, while JMJD5 with high phosphorylation levels significantly inhibited these effects (Fig. 7I-M, Additional file 1: Fig. S7F).