RPL17 and melanoma: The two pivotal adjuvant anti-PD-1 studies, the KEYNOTE-054 trial of pembrolizumab versus placebo in resected stage III melanoma and the CheckMate-238 trial of nivolumab versus ipilimumab in resected stage IIIB–IV melanoma, have both shown a clear and sustained recurrence-free survival (RFS) benefit in the anti-PD-1 treatment arm [15, 16].