IFNA1 and neoplasm: NO can react with superoxide anions to yield peroxynitrite, which nitrates with amino acids to form nitrotyrosine (nitration) and leads to the downregulation of the JAK/STAT pathway, contributing to IFN\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upalpha $$\end{document}α tolerance of tumor cells [15].