In this study, NOS1 deletion in melanoma up-regulated the expression of IFN\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upalpha $$\end{document}α regulating genes. The gene discussed is IFNA1; the disease is melanoma.