NOS2-derived NO inhibits the proliferation of effector T cells and downregulation of IFN\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upgamma $$\end{document}γ productions, but promotes the differentiation of regulatory T cells in tumor microenvironment [17]. The gene discussed is NOS2; the disease is neoplasm.