As shown in Fig. 4, the size of tumor nodes were significantly smaller in NOS1-KO groups (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\hbox {p}<0.001$$\end{document}p<0.001, Fig. 4A). Here, NOS1 is linked to neoplasm.