The xenograft mouse model experiment (NOS1-KO and WT A375 cells in BALB/c-nu mice, five mice for each genotype) showed that NOS1 deletion dramatically reduced the tumor sizes, which were measured by three diameters and tumor weights, (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\hbox {p} < 0.05$$\end{document}p<0.05, Fig. 1I). This evidence concerns the gene NOS1 and neoplasm.