Among 105 COVID-19 patients with ARDS, patients with DVT were older, had longer bedridden time, higher Well scores, higher SOFA scores, higher WBC counts, higher neutrophil counts, higher neutrophil-to-lymphocyte ratios, higher serum procalcitonin (PCT) levels, higher AST levels, higher alanine aminotransferase (ALT) levels, higher TBIL levels, higher DBIL levels, higher LDH levels, higher BUN levels, higher creatine kinase isoenzyme (CK)-MB levels, higher D-dimer levels, longer PT, and lower PaO2/FiO2 ratios compared to patients without DVT (all P <  0.05). The gene discussed is MB; the disease is acute respiratory distress syndrome.