There was positive significant correlation between Neutrophil–lymphocyte ratio and mRNA expression of TLR3 (rho = 0.62, P = 0.012), TLR7 (rho = 0.60, P = 0.013), TLR8 (rho = 0.49, P = 0.011), and TLR9 (rho = 0.39, P = 0.036) in all COVID-19 cases. This evidence concerns the gene TLR9 and COVID-19.