There was a significant positive correlation between percentage of oxygen saturation and transcript levels of TLR3 (rho = 0.37, P = 0.041), TLR7 (rho = 0.30, P = 0.026), TLR8 (rho = 0.35, P = 0.022), and TLR9 (rho = 0.39, P = 0.028) in the overall COVID-19 cases. This evidence concerns the gene TLR9 and COVID-19.