It was observed that oxygen saturation, WBC count, Neutrophil–lymphocyte ratio, LDH level, CRP level, and ESR level had a significant positive correlation with the transcript levels of TLR3, TLR7, TLR8, and TLR9 in the COVID-19 Group A as well as COVID-19 Group B patients. The gene discussed is TLR9; the disease is COVID-19.