There was a significant positive correlation between LDH level and mRNA expression of TLR3 (rho = 0.39, P = 0.041), TLR7 (rho = 0.41, P = 0.008), and TLR8 (rho = 0.49, P = 0.030) in the whole COVID-19 cases. This evidence concerns the gene TLR3 and COVID-19.