A significant positive correlation was observed between CRP and mRNA expression of TLR3 (rho = 0.85, P = 0.001), TLR7 (rho = 0.80, P = 0.004), TLR8 (rho = 0.78, P = 0.010), and TLR9 (rho = 0.48, P = 0.035) in the all COVID-19 cases. The gene discussed is TLR8; the disease is COVID-19.