TLR8 and COVID-19: There was a significant upregulation of mRNA of TLR3 (fold change = 2.4, P = 0.017), TLR7 (fold change = 2.0, P = 0.009), TLR8 (fold change = 2.2, P = 0.004), and TLR9 (fold change = 2.9, P = 0.010) in COVID-19-Group B compared with the Control-Group III (Table 3).