Functional enrichment analysis showed that the 10 hub genes (MX1, MX2, etc.)were enriched in RIG-I-like receptors (RLRs) signal pathway, Hepatitis C, Immune effector process, Response to virus, Response to type I interferon, and Response to cytokine, etc. (Fig. 5C, D). The gene discussed is MX1; the disease is hepatitis A virus infection.