CCN2 and congestive heart failure: In fact, evidence has shown that TMZ decreases collagen aggregation, connective tissue growth factor (CTGF) expression in cardiac fibroblasts, nicotinamide adenine dinucleotide phosphate-oxidase levels, and production of reactive oxygen species, with the positive impact of this drug on the treatment of congestive heart failure having been attributed to the mentioned mechanisms [6, 8].