These events affected important tumor-associated genes such as MDM2, MDM4, FoxM1, hRAS, Notch1, ATM, TGM2, Drosha, etc. Next, we divided all detected splicing changes into eight 8 types: (1) altered 3' splicing site, (2) altered 5' splicing site, (3) alternative mRNA end, (4) alternative mRNA start (strictly speaking, this change does not apply to splicing but results from the use of an alternative promoter), (5) single exon skip/add, (6) multiple exon skip/add, (7) mutually exclusive exons, and (8) intron retention (Fig. 2a). The gene discussed is MDM4; the disease is neoplasm.