In summary, our study expands from an atomic resolution understanding of the mode of action of M1 binding to the NEET proteins mNT and NAF-1, to observing corrective action on the cellular disorders induced by NEET protein deficiency in INS-1E β-cells and beyond finally to demonstrate the efficacy of M1 in correcting defective blood glucose homeostasis in a mouse model of diabetes. Here, NAF1 is linked to diabetes mellitus.