We detected decreased NK cell function in GBM patients, such as decreased NK cell-mediated cytotoxicity in PBMCs and NK cells (Fig. 1g, j) and lower IFN-γ secretion by PBMCs (Fig. 1h, l) as well as NK cells (Fig. 1k, l) when compared to those of healthy donors. This evidence concerns the gene IFNG and glioblastoma.