IFN-γ, secreted from split anergized NK cells, was shown to be primarily responsible for NK-mediated increase in tumor cell surface expression of MHC class I, CD54, which is intercellular adhesion molecule I (ICAM1), and programmed cell death receptor ligand 1 (PD-L1), a ligand for immune checkpoint protein PD-110,18,23. This evidence concerns the gene IFNG and neoplasm.