TLR4 and triple-negative breast carcinoma: ΔA146Ply, a mutant of pneumolysin (Ply) that lacks hemolytic activity, has been shown to inhibit autophagy in triple-negative breast cancer cells by activating toll-like receptor 4 (TLR4) and mannose receptor (MR), which suggests that ΔA146Ply may act on other cells that express TLR4 and MR.