To investigate whether RBMS1-depletion in tumor cells could enhance CAR-T cell activity, B7-H3 specific CAR-T cells (B7H3.CAR-T cells) [35] were co-cultured with RBMS1-depleted or control MB-MDA-231 cells expressing B7-H3 antigen (Fig. 8A). Here, CD276 is linked to neoplasm.