PLAT and diabetes mellitus: Secondary calcification, however, is associated with intraocular environmental changes, caused for example by surgical procedures (e.g., posterior lamellar keratoplasty, Pars-plana-Vitrectomy (PPV) or intracameral injection of recombinant tissue plasminogen activator) or linked to ocular and systemic disease (for example, diabetes mellitus)6,20,25–29.