To determine the contribution of FAM64A on FOXM1 transcriptional activity, HNSCC cells were co-transfected with FOXM1 and increasing amounts of FAM64A expression vectors, and the results showed that FAM64A increased FOXM1 transcriptional activity on the FOXM1 promoter in a dose-dependent manner (Fig. 3k). The gene discussed is FOXM1; the disease is head and neck squamous cell carcinoma.