We detected no TERT promoter mutations in 67 samples of PCNSL and SCNSL (Supplementary Data 5, Supplementary Fig. 10h), while the well-known TERT rs2853669 polymorphism, which has been associated with increased cancer risk140, was identified in 40% (14/35 (8 PCNSL, 6 SCNSL)) of the patients in the extension FFPE cohort. The gene discussed is TERT; the disease is cancer.