However, samples with mutational hotspots in BTG2, GRHPR, OSBPL10 and ZNF860 were significantly more frequent in PCNSL (in 18, 15, 11 and 11 of 30 samples, respectively) compared to ABC-like DLBCL (in 2, 0, 0 and 0 of 13 samples, p = 0.009, 0.001, 0.019 and 0.019, Fisher’s exact test, respectively). This evidence concerns the gene BTG2 and primary central nervous system lymphoma.