Given the role of the cGAS-STING signaling pathway in cardiac hypertrophy, we evaluated pyroptosis mediator proteins and proinflammatory cytokines in the hearts of DCM mice to identify whether cGAS-STING signaling pathway activation contributes to cardiomyocyte pyroptosis and the inflammatory response in DCM hearts. Here, STING1 is linked to familial dilated cardiomyopathy.