CGAS and familial dilated cardiomyopathy: The results showed that the cardiac function of DCM mice was decreased, as evidenced by the decreased ejection fraction, fraction shortening, E/A ratio and increased left ventricle internal dimension in systole (LVIDs), while cGAS and STING knockdown both significantly improved cardiac function in DCM mice (Fig. S1b in Additional File 1 and 2b).