HBEGF and acute lymphoblastic leukemia: For instance, Xu K et al. revealed that miR-96-5p upregulation could inhibit the proliferation of T-ALL cells through targeting HBEGF [14]; Saccomani V et al. showed that miR-22-3p upregulation could attenuate the progression of T-ALL via regulation of Notch1 signaling [4].