A recent seminal study showed that a higher HIV-1 viral set point in untreated patients during acute HIV-1 infection correlated positively with OXPHOS and that in vitro pharmacological inhibition of complex I (by rotenone or metformin) and complex III (by antimycin A) suppressed viral replication and immunometabolism through an NLRX1 and FASTKD5-dependent mechanism (Guo et al, 2021). This evidence concerns the gene FASTKD5 and HIV-1 infection.