CD274 and urothelial carcinoma: For combination therapy, there was also no evidence supporting the use of PD-L1 as a biomarker in urothelial carcinoma.34–36 In this study, antitumor responses were seen irrespective of PD-L1 expression, even patients with PD-L1 CPS<1 achieved an ORR of 31.6% (95% CI 12.6% to 56.6%).