Perlecan is another major component of BMs that we discuss later in the context of chondrodysplasias (see the section titled Perlecan and the section titled Chondrodysplasias: Schwartz–Jampel Syndrome Type 1 and Dyssegmental Dysplasia, Silverman–Handmaker Type) (115). Here, HSPG2 is linked to chondrodysplasia.