The observed changes in FC following iTBS treatment point to different brain networks known to be altered in depression, namely the SN (Manoliu et al., 2014) and the CEN (Kaiser et al., 2015): acting through the insula, the SN might be involved in negative symptom reduction, whereas the oxy-Hb modulation captured with fNIRS potentially reflects changes within the CEN. This evidence concerns the gene GSTM1 and major depressive disorder.