Alternate approaches to downregulate specific Notch receptors have included ASOs, and we demonstrated that Notch2 ASOs downregulate Notch2 expression in vitro and in vivo and ameliorate the osteopenia of mice harboring a Notch2 mutation replicating the one found in Hajdu Cheney Syndrome [38]. Here, NOTCH2 is linked to acroosteolysis dominant type.