However, in univariate analyses, no differences in the AF levels of endoglin, endostatin, haptoglobin, IGFBP-3, IGFBP-4, kallistatin, lumican, p-selectin, TGFBI, and VDBP were found to be associated with SPTD at <34 or <28 weeks after cerclage placement. The gene discussed is IGFBP4; the disease is atrial fibrillation.