On the other hand, the ability of cancer cells to evade apoptosis is a crucial feature for them, so that they frequently dysregulate the intrinsic apoptotic pathway to preserve tumor cell survival through upregulation of anti-apoptotic Bcl-2 family proteins, including Bcl2-A1, Bcl-2, Bcl-xL, Bcl-w, and Mcl-1 [8]. The gene discussed is BCL2; the disease is cancer.