EP300 and neoplasm: Notably, while silencing of the p300/GATA6 axis led to downregulation of the classical subtype gene signature (Figure 7A and Supplemental Figure 14A) and tumor morphological changes showing squamous features (Figure 1F, Figure 7, B and C, and Supplemental Figure 14B), we did not observe consistent changes in the basal-like subtype signature genes after EP300 knockout in HPAF-II tumors by our RNA-Seq.