While high-dose ETC-159 had no effect on the proliferation of parental PL45 cells, ETC-159 was able to suppress the growth of EP300-reexpressing cells in a dose-dependent manner (Figure 4E), supporting the model that EP300 determines Wnt dependency in RNF43-mutant pancreatic cancers. Here, EP300 is linked to familial pancreatic carcinoma.