Previous studies have identified a panel of RNF43-mutant pancreatic cancer cell lines, several of which have primary resistance to PORCN inhibitors (refs. 5, 21, and Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI156305DS1). The gene discussed is PORCN; the disease is familial pancreatic carcinoma.