However, these negative regulators of the Wnt/β-catenin pathway were neither mutated nor silenced in the existing PORCN inhibitor–resistant RNF43-mutant pancreatic cancer cell lines (Supplemental Figure 1A) based on genome, exome, and/or transcriptome sequencing results from public databases. The gene discussed is RNF43; the disease is familial pancreatic carcinoma.