Based on our observation that Wnt inhibition drives an increase in cancer cell–derived Wnt production (Figure 8C), we propose instead that the elevated expression of several Wnts in the GATA6-low pancreatic tumors (Figure 8A) is due to a compensatory feedback response, reacting to the loss of Wnt/β-catenin signaling. This evidence concerns the gene GATA6 and pancreatic neoplasm.