GATA6 and familial pancreatic carcinoma: Indeed, in our study, the established EP300-mutant GATA6-low cell lines Patu8988T and PL45 formed numerous metastases in vivo (Figure 1, C and D and Supplemental Figure 14B), consistent with the reported antimetastatic role of GATA6 in preclinical models of pancreatic cancer and the reduced GATA6 expression level in metastases of pancreatic cancer patients (62, 63).