RNF43 and pancreatic neoplasm: Interestingly, knockout of genes encoding β-catenin destruction complex components, i.e., APC and AXIN1/2, did not accelerate cell proliferation, indicating that either the function of β-catenin destruction complex had been completely inhibited or β-catenin–mediated transcription machinery had been saturated in RNF43-mutant pancreatic tumors.