CGAS and infection: Meanwhile, cGAS is critical for the induction of type I IFN response to infection by various bacteria such as Chlamydia trachomatis (Zhang et al., 2014), Mycobacterium tuberculosis (Watson et al., 2015), Listeria monocytogenes (Hansen et al., 2014), and Neisseria gonorrhoeae (Andrade et al., 2016).