In case of severe and uncontrolled hypertension, pregnant women with a solitary unilateral adrenal lesion suspected for cortical adenoma and biochemical values strongly suggestive for PA (marked aldosterone excess with serum values > 30 ng/dL, undetectable renin and spontaneous hypokalemia), because of their young age, can be directly referred for adrenalectomy without performing neither confirmatory test nor AVS [17, 63]. The gene discussed is REN; the disease is Hypokalemia.