RAG2 and primary biliary cholangitis: In mice, frequent injections with the bacterium Streptococcus intermedius resulted in PBC-like non-putrid cholangitis and an increase of circulating anti-gp210 (a crucial antibody in a subgroup of PBC patients); in the same mouse model, portal inflammation was induced in RAG2(− / −) mice by transferring splenic cells from S. intermedius–inoculated C57BL/6 wild-type mice [133].