PRTN3 and rheumatoid arthritis: Retention in patients with RF/ACPA single-positive RA was greater in biologic-naïve patients compared to those with ≥ 1 prior biologic treatment failure (50% vs 40%), while retention in patients with RF/ACPA double-negative RA was similar regardless of treatment line (biologic-naïve patients 37% vs 42% for those with ≥ 1 prior biologic treatment failure).